| ABSTRACT: |
|
Antitumor activities of compounds present in Juglans nigra (black
walnut) were studied in mice with spontaneous and/or transplanted tumors.
Swiss-Webster mice with mammary adenocarcinomas were treated for 9 d (ip)
with ellagic acid (EA; 50 mg/kg/d), juglone (J; 10 mg/kg/d), a strong
acids fraction (SA; 100 mg/kg/d) or a weak acids fraction (WA; 100
mg/kg/d); C57BL/65 mice with sc transplanted BW-10232 mammary
adenocarcinoma were treated ip with total alkaloids (50 mg/kg/d x 12) or
EA (10 mg/kg bid x 10 d). J decreased the tumor growth rate and body wt in
mice with spontaneous tumors. SA slightly decreased the growth rate of
spontaneous tumors, but WA (in mice with spontaneous tumors) and total
alkaloids (in mice with transplanted tumors) had no significant effect.
Body wt was not affected by SA, WA or total alkaloids. EA depressed the
growth of both tumors, especially the spontaneous tumors. Admin of EA
increased body wt in mice with spontaneous tumors, but decreased body st
in animals with transplanted tumors. |